Actin



Actin is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: α (Aa) (or G-actin) found in muscle tissue, β (Ab) and γ (Ag) actins are components of the cytoskeleton. F-actin is Aa bound to ATP. The images at the left and at the right correspond to one representative Actin, i.e. the crystal structure of rabbit Native G-actin (3hbt).

3D Structures of Actin
Update June 2011

α actin 1 (Aa)
2w49 – cAa +troponin C+ troponin T+ troponin I+ tropomyocin alpha-1 – chicken

1mdu – cAa+hGelsolin

3hbt, 2zwh, 1nwk, 1j6z, 3g37, 2y83 – rAa – rabbit

2q1n, 2q31, 2a5x, 1rdw, 1rfq, 1lcu – rAa – dimer

3mfp – rAa – Cryo EM

2q36, 1qz5 – rAa+kabiramide C – dimer

2hmp – rAa – protease cleaved

2zwh, 2gwj, 2gwk – rAa-ATP

2vyp – rAa+myxobacterial rhizopodin

2v51, 2v52 – rAa+mMKL/Myocardin-like protein – mouse (m)

2vcp – rAa+ neural wiskott-aldrich syndrome protein (hWASP) – human (h)

2a3z, 2a40, 2a41 – rAa+cDNase I+domains of hWASP – cow (c)

2ff3 - rAa+ hGelsolin +domains of hWASP

2a42 – rAa+cDNase I

3daw – rAa+mTwinfilin-1

3buz – rAa+Iota toxin component IA

3b5u – rAa filament – fiber diffraction

1eqy, 3cjb, 1p8z – rAa+hGelsolin

1rgi - rAa+hoGelsolin – horse (ho)

1t44 - rAa+hGelsolin:mThymosin B4

1esv - rAa+hGelsolin+ latrunculin A

3cjc - rAa+hGelsolin+cDNase I

2d1k - rAa+hWH2 domain of MIN+cDNase I

2pbd – rAa+hProfilin-1

2pav - rAa+hProfilin-1+hVASP

2q97 – rAa+toxofilin – Toxoplasma gondii

2q0r – rAa+pectenotoxin-2

2q0u - rAa+pectenotoxin-2+latrunculin B

1ijj - rAa+latrunculin A

2fxu – rAa+bistramide A

1wua – rAa+alpyronine A

2asm, 2asp – rAa+reidispongiolide

2aso – rAa+sphinxolide B

1yxq – rAa+swinholide A

1y64 – rAa+yBNI1 domain FH2 - yeast

1sqk – rAa+DmCiboulot - Drosophila melanogaster (Dm)

3mn5 – rAa+ DmSpire WH2 domain

2ff6 - rAa+DmCiboulot+hGelsolin

1s22 – rAa+ulapualide A

1qz6 – rAa+jaspisamide A

1lot, 1kxp, 1ma9 – rAa+hVitamin D binding protein 3m1f – rAa+VOPL WH2 domain

3m3n – rAa+mN-WASP

3m6g – rAa+lobophorolide

β actin (Ab)
3lue – hAb+hAlpha-actinin

3byh – hAb+hFimbrin ABD2 – Cryo EM

2oan – cAb

γ 1 actin (Ag)
1atn – rAg+cDNase I

3chw – Major DdAg+hProfilin+poly-Pro repeat – Dictyostelium discoideum

3ci5, 3cip, 1nmd - Major DdAg+hGelsolin

3a5l, 3a5m, 3a5n, 3a5o - Major DdAg+hGelsolin (mutant)

1c0g, 1dej – DdAg:tetrahymenatA+hGelsolin

1nm1 - DdAg+hGelsolin+Mg-ATP

1nlv, 1c0f – DdAg+hGelsolin

1d4x – Ag 1/3+hGelsolin – C. elegans

1h1v – hAg+rGelsolin

1hlu, 2btf – cA+cProfilin

1o1g, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o18, 1o19, 1mvw, 1m8q –cAg+cMyosin II - tomography

3eks – DmAg 5c (mutant)

3eku – DmAg 5c (mutant)+cytochalasin D

3el2, 2hf4 - DmAg 5c (mutant)+Ca-ATP

2hf3 - DmAg 5c (mutant)+Ca-ADP

3b63 – actin filament – Limulus polyphemus

1yvn – yA (mutant)+hGelsolin

1yag - yA+hGelsolin

3mmv – DmA-5C+spire WH2 domain

3mn6, 3mn7, 3mn9 - DmA-5C (mutant)+spire